Amoxicillin Syrup

Amoxicillin Syrup – Full Introduction

Amoxicillin syrup is a broad-spectrum antibiotic belonging to the penicillin (β-lactam) class, commonly prescribed for bacterial infections in children. The syrup formulation is preferred in pediatrics due to ease of administration and accurate weight-based dosing.

---

Drug Class

• Aminopenicillin

• β-lactam antibiotic

---

Mechanism of Action

Amoxicillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to:

• Disruption of cell wall formation

• Weakening of the bacterial cell wall

• Bacterial cell lysis and death

It is bactericidal and effective mainly against gram-positive and some gram-negative bacteria.

---

Therapeutic Uses

• Upper respiratory tract infections (tonsillitis, pharyngitis, sinusitis)

• Lower respiratory tract infections (bronchitis, pneumonia)

• Otitis media (ear infection)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Dental infections

• Part of H. pylori eradication therapy (with other drugs)

---

Benefits

• Broad antibacterial coverage

• Well tolerated in children

• Good oral absorption

• Pleasant taste improves compliance

• Safe for use in infants and children

---

Common Side Effects

• Diarrhea

• Nausea or vomiting

• Abdominal discomfort

• Skin rash

---

Serious but Rare Side Effects

• Severe allergic reactions (anaphylaxis)

• Stevens–Johnson syndrome (very rare)

• Antibiotic-associated colitis

• Liver enzyme elevation (rare)

---

Contraindications & Precautions

• Known penicillin allergy

• History of severe hypersensitivity reactions

• Use with caution in patients with infectious mononucleosis (may cause rash)

• Adjust dose in renal impairment

---

Dosage & Administration

• Children: Dose based on body weight and severity of infection

• Common dosing: 20–45 mg/kg/day in divided doses

• Available strengths: 125 mg/5 mL, 250 mg/5 mL

• Shake well before use

• Complete the full course even if symptoms improve

---

Conclusion

Amoxicillin syrup is a safe, effective, and commonly prescribed pediatric antibiotic for a wide range of bacterial infections. Proper dosing, allergy screening, and completion of the full treatment course are essential to ensure effectiveness and prevent antibiotic resistance.