Ibuprofen Syrup (Brufen)

Ibuprofen Syrup (Brufen) – Full Introduction

Ibuprofen syrup, commonly known by the brand name Brufen, is a non-steroidal anti-inflammatory drug (NSAID) used mainly in children for the treatment of pain, fever, and inflammation. It is widely prescribed due to its effectiveness and availability in palatable liquid formulations.

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Drug Class

• Non-steroidal anti-inflammatory drug (NSAID)

• Analgesic

• Antipyretic

• Anti-inflammatory

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Mechanism of Action

Ibuprofen works by inhibiting cyclo-oxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, fever, and inflammation. By reducing prostaglandin production, ibuprofen:

• Relieves pain

• Reduces fever

• Decreases inflammation

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Therapeutic Uses

• Fever in children

• Mild to moderate pain such as:

  • Teething pain

  • Earache

  • Sore throat

  • Headache

  • Musculoskeletal pain

• Inflammatory conditions (e.g., juvenile idiopathic arthritis)

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Benefits

• Effective antipyretic and analgesic

• Provides anti-inflammatory action (unlike paracetamol)

• Longer duration of action than paracetamol

• Suitable alternative when paracetamol alone is insufficient

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Common Side Effects

• Gastrointestinal upset (nausea, vomiting, abdominal pain)

• Heartburn

• Dizziness

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Serious but Rare Side Effects

• Gastric irritation, ulceration, or bleeding

• Kidney impairment (especially with dehydration)

• Allergic reactions (rash, bronchospasm)

• Increased risk of cardiovascular events (with long-term use)

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Contraindications & Precautions

• History of peptic ulcer disease or GI bleeding

• Severe renal impairment

• Known hypersensitivity to NSAIDs

• Dehydrated children (risk of kidney injury)

• Asthma triggered by NSAIDs

• Use cautiously in infants under 6 months (only on medical advice)

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Dosage & Administration

• Children: 5–10 mg/kg per dose every 6–8 hours

• Maximum: 40 mg/kg/day

• Common strengths: 100 mg/5 mL, 200 mg/5 mL

• Give after food or milk to reduce stomach irritation

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Conclusion

Ibuprofen syrup (Brufen) is a highly effective medication for fever, pain, and inflammation in children. When used at the correct dose and with proper hydration, it is safe and reliable. However, caution is needed in children with kidney disease, dehydration, or gastrointestinal conditions.