Paracetamol Syrup – Full Introduction
Paracetamol syrup is a liquid oral formulation of paracetamol (acetaminophen) designed mainly for infants and children, though it may also be used in adults who have difficulty swallowing tablets. It is widely used as an analgesic (pain reliever) and antipyretic (fever reducer).
Drug Class
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Analgesic
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Antipyretic
Mechanism of Action
Paracetamol works primarily in the central nervous system (CNS) by:
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Inhibiting prostaglandin synthesis in the brain
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Reducing the pain threshold
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Acting on the hypothalamic heat-regulating center to lower fever
It has minimal anti-inflammatory activity and does not significantly affect gastric mucosa or platelet function.
Therapeutic Uses
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Fever (pyrexia) in infants and children
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Mild to moderate pain such as:
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Teething pain
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Headache
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Earache
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Sore throat
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Post-immunization fever
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Adjunct in post-operative pain management
Benefits
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Safe and effective when used at recommended doses
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Suitable for infants, children, and elderly patients
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Gentle on the stomach compared to NSAIDs
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Low risk of allergic reactions
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Pleasant taste improves pediatric compliance
Common Side Effects
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Generally well tolerated
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Mild gastrointestinal upset (rare)
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Skin rash (rare)
Serious but Rare Side Effects
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Liver toxicity in overdose or prolonged excessive use
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Severe allergic reactions (very rare)
Contraindications & Precautions
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Severe liver disease
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Known hypersensitivity to paracetamol
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Avoid simultaneous use of multiple paracetamol-containing products
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Use caution in malnourished children or those with chronic illness
Dosage & Administration
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Children: 10–15 mg/kg per dose every 4–6 hours
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Maximum: 4 doses in 24 hours
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Strengths commonly available: 120 mg/5 mL, 125 mg/5 mL, 250 mg/5 mL
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Shake well before use and use a measuring spoon or syringe
Conclusion
Paracetamol syrup is a safe, reliable, and commonly used medication for managing fever and mild pain in children. When administered in correct doses, it provides effective relief with minimal side effects. Care should be taken to avoid overdose to prevent liver damage.
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